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        Nc2Eye

           A curated ncRNAomics knowledgebase for bridging basic and clinical research in eye diseases.

Detail of age-related macular degeneration (AMD)
ncRNA name C3 siRNA
ncRNA Category siRNA
Disease name age-related macular degeneration (AMD)
Species Mus musculus
Tissues/Cell_line retinas
Methods immunohistochemistry, in situ hybridization, qRT-PCR
Expression pattern associated
Functional description Local suppression of C3 expression using siRNA inhibited complement activation and deposition, and reduced cell death.
PubMed ID 28605809
Year 2017
Title Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration.
Drug-related ncRNA NO

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